【Shenzhen University: Self assembling origami structure empowers' ultra sensitive optoelectronic biosensors'】

According to the International Agency for Research on Cancer (IARC), there are an estimated 19.974 million new cancer cases and 9.744 million deaths worldwide in 2022. Among them, the number of new cases of lung cancer reached 2.481 million, accounting for 12.4% of the global new cases of cancer. Lung cancer has once again become the most influential cancer in the world, and is one of the fastest growing malignant tumors in terms of incidence rate and mortality. However, most cases of lung cancer are detected in the late stages, so researching new methods for early cancer screening is a strategic issue that concerns the fate and health of humanity. In clinical treatment research, it has been found that early screening, prevention, and treatment of cancer can be achieved by detecting cancer gene markers in human samples.

Recently, the research groups of Professor Zhang Han and Professor Shao Yonghong from the School of Physics and Optoelectronic Engineering at Shenzhen University have made progress in the field of biosensors based on new laser applications. This biosensor device utilizes self-assembled origami structure to upgrade the biosensor chip, combined with the single base recognition ability of CRISPR gene scissors technology, and achieves Z-molar level detection of cancer targets through self-developed SPR equipment. It provides great potential for application in the field of early screening and diagnosis of cancer.