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【Wuhan University: Research on microfluidic electrochemical integrated sensors for rapid, efficient separation and sensitive detection of pathogenic bacteria】

Pathogens, including fungi, bacteria, and viruses, are the sources of infection that cause diseases. Candida albicans, as an opportunistic pathogen, is present in the oral cavity, intestines, and vagina of 40-80% of normal individuals. Traditional pathogen detection methods are time-consuming, inefficient, and highly sensitive, which affects infection control and leads to disease deterioration. It is very important to diagnose pathogenic diseases and guide the rational use of antibiotics in clinical practice.

Xie Min from Wuhan University has developed a method to treat these problems and studied the Microfluidic Electrochemical Integrated Sensor (MEIS), which has the function of rapid, efficient separation and sensitive detection of pathogenic bacteria. Successfully assembled three-dimensional macroporous PDMS and Au nanotube electrodes into modeling microchips, serving as "three-dimensional chaotic flow separators" and "electrochemical detectors", respectively.The microfluidic electrochemical integrated sensor can successfully isolate Candida albicans in the range of 30-3000000 CFU in saliva matrix, with a capture efficiency of over 95%, and sensitively detect Candida albicans in oral saliva samples within 1 hour.